Using CBD Oil for Anxiety: Does It Work?
Cannabidiol (CBD) is a type of cannabinoid, a chemical found naturally in cannabis (marijuana and hemp) plants. Early research is promising regarding the ability of CBD oil to help relieve anxiety.
Unlike tetrahydrocannabinol (THC), another type of cannabinoid, CBD doesn’t cause any feelings of intoxication or the “high” you may associate with cannabis.
Learn more about the potential benefits of CBD oil for anxiety, and whether it could be a treatment option for you.
The human body has many different receptors. Receptors are protein-based chemical structures that are attached to your cells. They receive signals from different stimuli.
CBD is thought to interact with CB1 and CB2 receptors. These receptors are mostly found in the central nervous system and the peripheral nervous system, respectively.
The exact way CBD affects CB1 receptors in the brain isn’t fully understood. However, it may alter serotonin signals.
Serotonin, a neurotransmitter, plays an important role in your mental health. Low serotonin levels are commonly associated with people who have depression. In some cases, not having enough serotonin may also cause anxiety.
The conventional treatment for low serotonin is a selective serotonin reuptake inhibitor (SSRI), such as sertraline (Zoloft) or fluoxetine (Prozac). SSRIs are only available by prescription.
Some people with anxiety may be able to manage their condition with CBD instead of an SSRI. However, you should talk to your doctor before making changes to your treatment plan.
Several studies point to the potential benefits of CBD for anxiety.
For generalized anxiety
For generalized anxiety disorder (GAD), the National Institute on Drug Abuse (NIDA) says that CBD has been shown to reduce stress in animals such as rats.
Study subjects were observed as having lower behavioral signs of anxiety. Their physiological symptoms of anxiety, such as increased heart rate, also improved.
More research needs to be done, specifically on humans and GAD.
For other forms of anxiety
CBD may also benefit people with other forms of anxiety, such as social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD). It may help treat anxiety-induced insomnia as well.
In 2011, a study researched CBD’s effects on people with SAD. Participants were given an oral dose of 400 milligrams (mg) of CBD or a placebo. Those who received CBD experienced overall reduced anxiety levels.
Multiple recent studies have shown that CBD can help with PTSD symptoms, such as having nightmares and replaying negative memories. These studies have looked at CBD as both a standalone PTSD treatment as well as a supplement to traditional treatments like medication and cognitive behavioral therapy (CBT).
For other neurological disorders
CBD has also been studied in other neurological disorders.
A 2017 literature review on CBD and psychiatric disorders concluded that there isn’t enough evidence to tout CBD as an effective treatment for depression.
The authors did find some evidence to suggest that CBD could help with anxiety disorders. However, these studies were uncontrolled. This means that the participants weren’t compared to a separate group (or “control”) that might have received a different treatment — or no treatment at all.
Based on their review, more human tests are needed to better understand how CBD works, what the ideal dosages should be, and if there are potential side effects or hazards.
A 2016 study found that CBD can have antipsychotic effects in people with schizophrenia. Moreover, CBD doesn’t cause the significant debilitating side effects associated with some antipsychotic drugs.
If you’re interested in trying CBD oil for your anxiety, talk to your doctor. They can help you figure out a starting dosage that’s right for you.
However, the nonprofit National Organization for the Reform of Marijuana Laws (NORML) does advise that very few commercially available products contain enough CBD to replicate the therapeutic effects seen in clinical trials.
In a 2018 study, male subjects received CBD before undergoing a simulated public speaking test. The researchers found that an oral dose of 300 mg, administered 90 minutes before the test, was enough to significantly reduce the speakers’ anxiety.
Members of the placebo group and study subjects who received 150 mg saw little benefit. The same was true for subjects who received 600 mg.
The study only looked at 57 subjects, so it was small. More research, including studies that look at female subjects, is needed to determine the appropriate dosage for people with anxiety.
CBD is generally considered safe. However, some people who take CBD may experience some side effects, including:
- changes in appetite
- changes in weight
CBD may also interact with other medications or dietary supplements you’re taking. Exercise particular caution if you take medications, such as blood thinners, that come with a “grapefruit warning.” CBD and grapefruit both interact with enzymes that are important to drug metabolism.
One study on mice found that being gavaged with, or force-fed, CBD-rich cannabis extract increased their risk for liver toxicity. However, some of the study mice had been given extremely large doses of CBD.
You shouldn’t stop taking any medications you’re already using without talking to your doctor first. Using CBD oil may help your anxiety, but you could also experience withdrawal symptoms if you suddenly stop taking your prescription medications.
Symptoms of withdrawal include:
Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level, but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level, but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and may be inaccurately labeled.
In some parts of the United States, CBD products are only allowed for specific medical purposes, such as the treatment of epilepsy. You may need to get a license from your doctor to be able to purchase CBD oil.
If cannabis is approved for medical use in your state, you may be able to purchase CBD oil online or in special cannabis clinics and dispensaries. Check out this guide to 10 of the best CBD oils on the market.
As research on CBD continues, more states may consider the legalization of cannabis products, leading to wider availability.
Find out what the research says about CBD oil and anxiety. Also get the facts on how it affects other disorders and its legal status.
Drug Interactions between cannabidiol and Zoloft
This report displays the potential drug interactions for the following 2 drugs:
- Zoloft (sertraline)
Interactions between your drugs
Applies to: Zoloft (sertraline) and cannabidiol
Using sertraline together with cannabidiol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
Applies to: Zoloft (sertraline)
You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can increase the nervous system side effects of sertraline such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. Talk to your doctor or pharmacist if you have any questions or concerns.
Applies to: cannabidiol
Food may affect the absorption and blood levels of cannabidiol. To avoid significant fluctuations in blood levels of the medication, cannabidiol should be taken about the same time each day consistently either with or without food. Consumption of grapefruit and grapefruit juice should be limited, as it may increase the blood levels of cannabidiol. Patients who consume grapefruit or grapefruit juice may require a lower dosage of the medication based on blood levels. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
- Cannabidiol Drug Interactions
- cannabidiol General Consumer Information
- Zoloft Drug Interactions
- Zoloft General Consumer Information
- Drug Interactions Checker
Drug Interaction Classification
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|Unknown||No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some mixtures of medications can lead to serious and even fatal consequences.
A Moderate Drug Interaction exists between cannabidiol and Zoloft. View detailed information regarding this drug interaction.